The U.S. Preventive Services Task Force (USPSTF) sets health guideline recommendations for physicians to follow. In 2023, the task force recommended that colon cancer screening should begin once an individual turns 45 years old, which was five years younger than the previous guideline.

That's expected to change again when the USPSTF revisits guidelines in 2026. Considering colon cancer is becoming more common in younger individuals, including those in their 30s, the age threshold for screening could drop by a decade.

For now, if individuals receive a negative Cologuard result, then the American Cancer Society recommends getting rescreened every three years. The USPSTF and ACS recommendations work in tandem: The younger the recommended age for a first screen, the greater the number of potential rescreens over an individual's lifetime.

Rescreens are becoming an increasingly large source of revenue for Cologuard. Consider how the number of individuals eligible for a second or third rescreen is evolving.