Five different PD-1 inhibitors generate at least $1 billion in annual revenue as of 2024, including Keytruda, the bestselling drug of all time. The entire drug class generated over $45 billion in global revenue in 2023, the most of all-time. But advances in precisely targeting the tumor microenvironment could make them even more valuable.

Crops engineered with genetic traits dominate major American crop acreage because they provide farmers value, convenience, and greatly improved yields.

A simple genetic edit to insert the OxO gene protects American chestnut trees against the invasive blight that rendered these natural titans functionally extinct. It could also become a national security interest by accelerating the availability of affordable housing.